Cisplatin a549

WebJan 1, 2024 · Results: Hypoxia exacerbated the cisplatin resistance in lung cancer cells due to the increased expression of PKM2 that was observed in the exosomes secreted by hypoxic cisplatin-resistance cells. We identified that hypoxia-induced exosomal PKM2 transmitted cisplatin-resistance to sensitive NSCLC cells in vitro and in vivo. WebCisplatin (DDP) has been a significant tumor chemotherapy against various solid malignant tumors, including lung adenocarcinoma, since it was approved by the Food and Drug …

Enhanced expression of lncRNA ZXF1 promotes cisplatin …

WebMay 17, 2024 · Cisplatin and phenanthriplatin modulate long-noncoding RNA expression in A549 and IMR90 cells revealing regulation of microRNAs, Wnt/β-catenin and TGF-β signaling Scientific Reports Article... WebApr 8, 2024 · A549 cells were seeded at a density of 3×10 4 cells/well for the C group (sensitive cells) and 9×10 4 cells/well for the CIS population (resistant cells) in 96-well … chloemmm hair https://rockadollardining.com

Deferoxamine Counteracts Cisplatin Resistance in A549 Lung

WebNov 1, 2024 · A549 Cells Aged Animals Antineoplastic Agents, Immunological / administration & dosage* Antineoplastic Agents, Immunological / pharmacology B7-H1 Antigen / genetics* B7-H1 Antigen / metabolism* Carcinoma, Non-Small-Cell Lung / drug therapy* Carcinoma, Non-Small-Cell Lung / genetics Carcinoma, Non-Small-Cell Lung / … WebThe IC 50 of cisplatin on A549 cells was 4.07±0.32, 2.26±0.43, and 1.52±0.41 µg/mL, for 24, 48, and 72 hours, respectively. Thus, we used 4, 2, and 1 µg/mL of cisplatin to treat A549 cells... WebJun 12, 2024 · Based on a published set of sequencing data, we find that hsa_circ_0001946 is a circRNA molecule with a significantly different expression level in three cell lines (human normal lung fibroblasts cell line MRC-5, human NSCLC cell line A549, cisplatin-resistant cell line A549/DDP), NSCLC tissues and paired adjacent normal tissues. grass valley celtic festival 2022

Hypoxia-induced PVT1 promotes lung cancer chemoresistance to …

Category:Asiatic acid re-sensitizes multidrug-resistant A549/DDP cells to ...

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Cisplatin a549

Generation and characterisation of cisplatin-resistant non

WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist effects. Aptamer-targeted nano-zinc carriers were loaded with USP14 siRNA to … WebSep 23, 2024 · Taken together, novel toxicological-related mechanisms by AgNPs-GA were proposed involving the generation of ROS that causes DNA damage which led to programmed cell death in both A549 and BEAS-2B cells.

Cisplatin a549

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WebThe addition of TAS reduced the IC 50 value of cisplatin in A549 and H1299 cells, indicating that TAS can significantly increase the sensitivity of lung cancer cells to cisplatin. Additionally, to determine the effects of the combination of TAS and cisplatin on the apoptosis of NSCLC cells, flow cytometry was used to detect the apoptosis rate ... WebOct 1, 2024 · Cisplatin-resistant A549 cells (A549/CisR) were derived from A549 cells by continuous cisplatin treatment. The original parental A549 cells were initially treated …

WebWe previously had obtained cisplatin-resistant non-small cell lung cancer (NSCLC) A549 cell lines (A549/DDP) and its parental A549 cells. 12,13 In this study, we aim to observe the difference of autophagy between A549/DDP and A549, and also determine the role autophagy plays and the underlying regulation mechanisms during DDP treatment in … WebJul 26, 2024 · The efficacy of cisplatin-based chemotherapy in cancer is limited by the occurrence of innate and acquired drug resistance. In order to better understand the …

WebFeb 28, 2024 · All of these new complexes have been tested on three human cancer cell lines (A549 lung, SKOV3 ovarian, and MCF-7 breast cancer cell lines) and studied for … WebFeb 28, 2024 · All the new complexes showed cytotoxicity in vitro against the three cancer cell lines, but only complex 1a showed statistically significant different activity compared with cisplatin, with significantly lower IC 50 values, 4.31, 6.23, and 4.80 μM, compared with 9.71, 14.48, and 11.59 μM for cisplatin against A549, SKOV3, and MCF-7 ...

WebNov 29, 2024 · Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment Yanyun Gao, …

WebWe used the lung cancer cell line, A549, to determine the effects of the curcuminoids and cisplatin on cell viability and several apoptotic signaling mechanisms. Cellular viability … grass valley central kitchenWebNov 29, 2024 · This study revealed that cisplatin resistant A549 lung cancer cells can be identified by their increased levels of mitochondrial mass. However, Mito-High cells … chloe moffatWebIn addition, GA reduced the MRP2 and LRP protein expression level in A549/DDP cells. GA inhibits the proliferation, induces cell cycle arrest and apoptosis in A549/DDP cells. … chloe mod rectangle 55mm sunglassesWebEffect of MiR-195-5p on the Sensitivity of A549 and A549/DDP Cells to Cisplatin Sensitivity to cisplatin in the different groups was measured as the IC 50 concentration after … chloe missing childWebFeb 28, 2024 · The approximately 85% of lung cancers are non-small cell lung cancer (NSCLC), with dismal median overall survival and 5-year survival rates due to recurrence, extensive invasion and metastasis 2-4. Cisplatin (DDP) is a first-line cytotoxic agent for the treatment of human NSCLC. grass valley cgp 500WebMay 11, 2012 · As shown in Figures 2a and b, apoptosis were induced in both A549 and H460 cells when they were treated with cisplatin alone (10 and 12.45%, respectively), … grass valley ca wineriesWebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung … grass valley celtic festival